Senior/Principal Scientist (DMPK) - Simcyp

Closing Date for Applications: Midnight (UK time), Sunday 5^th February 2017
Line of Management: Head of Translational Science in DMPK team
Holiday Entitlement: 25 days, plus statutory bank holidays

Job Overview:

We have an immediate opening for a Senior/Principal Scientist with a background in drug metabolism and pharmacokinetics. The candidate should have familiarity with in vitro-in vivo extrapolation (IVIVE) approaches and physiologically based pharmacokinetic modelling. Experience working in drug discovery/development within the Pharmaceutical Industry is desirable.

The successful candidate will join an internationally recognised, multidisciplinary research team, providing opportunities for further development of knowledge and skills. In addition to leading a group of scientists, the successful candidate will undertake novel research projects to further expand the capabilities of the Simcyp Simulator which requires a high level of attention to detail, good oral and written communication skills and the ability to liaise effectively with the Software Development team. In addition the successful candidate will be expected to provide on-going customer support, education and training related to the use of the Simulators, and to act as tutor on the workshop programme. The post does not include routine laboratory or clinical work.

We offer a unique and exciting mix of academic and commercial environments which encourage regular attendance at scientific meetings as part of our continuous education programs.

Requirements:

Essential

• PhD (or equivalent experience) in a relevant field with several years of practical experience.
• Knowledge of in vitro assays used in drug metabolism and pharmacokinetic studies and their application in IVIVE approaches.
• Knowledge of PK/PD properties of small and/or large molecules
• Demonstrable communication skills, as evident by presentation at scientific meetings, and good interpersonal and organizational skills.
• Track record of publications in peer-reviewed literature.
• Experience of managing other scientists.

Desirable

• Some understanding of modelling and simulation principles of physiological and biological systems and parameter estimation techniques.
• Experience in prediction of drug-drug interactions.
• Awareness of R&D process in pharmaceutical companies.

Company Overview:

Simcyp is part of Certara, a company which combines sophisticated research and development informatics with the power of predictive science methodologies to span the drug development spectrum and offer pharma a previously unavailable ‘end-to-end’ solution in the quest for improving human health. The Simcyp team conducts cutting-edge research and provides consultancy, knowledge integration tools, algorithms, modelling solutions and databases (implemented in its globally-recognised Simcyp Population-based Simulator) for a client base of major blue-chip pharmaceutical and biotechnology organisations. Simcyp focuses, in particular, on gathering information required for the modelling and simulation (M&S) of the individual time-course and fate of drugs. We are on course to become the global industry standard, consequently, there is a continuous requirement for high quality people to join us, help in our expansion and share in our success.

Applications:

Please send your CV, covering letter and the names of two references quoting the job reference/title to simcyp.recruitment@certara.com OR apply via our website