PhD Studentship: Computer Modelling of Synergistic Effects in Transport and Metabolism

Department of Chemistry

Vacancy Reference No: MA07923

Limit of tenure applies*

A PhD studentship is available from October 2011 under the supervision of Professor Glen in a collaborative project with Lhasa Ltd to develop computer models for the prediction of metabolism and toxicity.

Low oral bioavailability for many drugs is generally attributed to poor solubility in the gastrointestinal fluids, poor gut membrane permeability and/or extensive hepatic first-pass elimination. Increasingly however, it has been recognized that concomitant metabolism in the intestine and P-glycoprotein counter-transport processes may also contribute significantly to reduce bioavailability of drugs and nutrients. Metabolising enzymes in the intestine, gut microflora and transport processes may work synergistically to reduce toxic effects of molecules or facilitate the absorption of nutrients. Recently, a strong overlap has been identified between substrates for gut metabolism by cytochrome P-450 3A and gut counter-transport by P-glycoprotein, suggesting that these processes may work together to limit the bioavailability of a large number of drug substances. We wish to develop computational models that will combine drug metabolism and transport using available data, computational models and simulation to better understand the relationship between metabolism and transport.

Applicants should have, or be about to receive, at least the equivalent of a UK II.1 honours degree in a relevant discipline. The studentship covers tuition fees plus a maintenance grant for UK and other EU nationals who are eligible for the Home/EU fees rate. Non-EU nationals may apply if they have funding in place to cover the fees differential for overseas students.

Applications should include a CV, contact details for two professional referees, and should be sent to Professor Robert Glen, Department of Chemistry, Lensfield Road, Cambridge CB2 1EW (email: rcg28@cam.ac.uk).

* Limit of tenure: 42 months.

Closing date: 11 April 2011.

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