Post-doctoral Research Fellow: Structural Biology of Amyloid Fibrils

University of Leeds -Biological Sciences

Fixed term for 3 years (with possible extension beyond 4 years depending on funding), available immediately or could be started early in 2014

ERC Advanced Grant “Amyloid Fibril Cytotoxicity: New Insights from Novel Approaches”

You will join our interdisciplinary ERC-funded team using structural, biophysical and cell biological methods to investigate the molecular mechanisms of protein aggregation into amyloid fibrils in vitro, and the effects of aggregated/disaggregated species on cellular homeostasis. This large programme involves collaboration between the groups of Professor Sheena Radford and Drs Neil Ranson, David Brockwell, Eric Hewitt and Professor Alison Ashcroft within the Astbury Centre for Structural Molecular Biology. Ultimately, the programme of research will involve the appointment of four post-doctoral fellows.

You will have experience in structural biology or advanced imaging. You will use a wide range of imaging techniques to study the structure of amyloid aggregates and the interactions they make with biological membranes. Experience in cryo-electron microscopy/tomography will be an advantage, as this will form a major component of the research project, but training will be offered to excellent candidates lacking this experience. In addition, we will also use super-resolution light microscopy (PALM, STORM and SIM). The post will suit a talented researcher with a passion for structural biology and/or advanced imaging techniques, and the drive and enthusiasm needed to learn new skills. You will join an integrated, well-funded team of three post-doctoral fellows, who will use Protein Chemistry (NMR), Dynamic Force Spectroscopy and Cell Biology to achieve our project aims.

You should have (or be close to completing) a PhD in structural molecular biology, biophysics, or a related discipline.

University Grade 7 (£30,424 - £36,298 p.a.)

Informal enquiries may be made to Professor Sheena E Radford, email s.e.radford@leeds.ac.uk or Dr Neil Ranson, email n.a.ranson@leeds.ac.uk.

Closing Date: 27 November 2013

(Redeployment Closing Date: 13 November 2013)

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