Header

Computer biologist / Bioinformatician in chromatin epigenetics


Applications are invited from ambitious and motivated post-doc candidates to work with Dr. Adam West and Dr. David Vetrie to use computational and informatics-based approaches to study the epigenetics of chromatin structure and chromosomal domain organisation in mammals. Applicants must possess strong programming and data analysis skills and familiarity with Python and/or Perl and Linux shell programming. Candidates should also have strong communication skills and an ability to adapt to new ideas and learn new techniques. The role will include analysis of large datasets from state-of-the-art approaches, including ChIP-seq, RNA-seq and methyl-seq.
We are based in the Institute for Cancer Sciences, with new state-of-the-art research facilities. This project is well funded by the BBSRC and overseas governments. There will be opportunity to work closely with other leading labs in the field, in the United States and Europe. Glasgow is a vibrant and forward-looking European city, situated close to some of Europe’s most beautiful countryside.
Additional information at www.adamwest.co.uk
This post has funding available for 3 years in the first instance.
Apply online at www.glasgow.ac.uk/jobs. Ref M00505.
Closing date: 9th December 2012
The University is committed to equality of opportunity in employment.
The University of Glasgow, charity number SC004401.

Relevant publications:
1: Hassan-Zadeh V, Chilaka S, Cadoret JC, Ma MK, Boggetto N, West AG and Prioleau MN. USF binding sequences from the HS4 insulator element impose early replication timing on a vertebrate replicator. PLoS Biol. 2012, 10:e1001277.
2. Ma MK, Heath C, Hair A and West AG. Histone crosstalk directed by H2B ubiquitination is required for chromatin boundary integrity. PLoS Genet. 2011 7:e1002175.
3: Dhami P et al. Complex exon-intron marking by histone modifications is not determined solely by nucleosome distribution. PLoS One. 2010, 5:e12339.
4: Dhami P et al. Genomic approaches uncover increasing complexities in the regulatory landscape at the human SCL (TAL1) locus. PLoS One. 2010, 5:e9059.
5: Dickson J, Gowher H, Strogantsev R, Gaszner M, Hair A, Felsenfeld G and West AG. VEZF1 elements mediate protection from DNA methylation. PLoS Genet. 2010, 6:e1000804.
6: Bruce AW et al. Functional diversity for REST (NRSF) is defined by in vivo binding affinity hierarchies at the DNA sequence level. Genome Res. 2009, 19:994-1005.
7: ENCODE Project Consortium. Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project. Nature. 2007 447(7146):799-816.
8: Koch CM et al. The landscape of histone modifications across 1% of the human genome in five human cell lines. Genome Res. 2007, 17:691-707. 
To apply
Apply online at www.glasgow.ac.uk/jobs, reference number M00505.
Closing date: 9th December 2012.